Lawson Laboratory In the Department of Reproductive Medicine

Lawson Lab Publications

Here is a list of our research publications. Journal links take you to the on line version of the publications.  Click PDF links to download the PDF file.

2018-Li Li, S., E. F. Mbong, D. T. John, T. Terasaka, D. Li, and M. A. Lawson (2018). "Induction of stress signaling in vitro and suppression of gonadotropin secretion by free fatty acids in female mouse gonadotropes." Endocrinology 159 (2):1074-1087.
Terasaka Fig1 Terasaka, T., M. E. Adakama , S. Li, T. Kim, E. Terasaka, D. Li, and M. A. Lawson (2017) "Reactive oxygen species link gonadotropin-releasing hormone receptor signaling cascades in the gonadotrope." Front. Endocrinol. 8:286. doi: 10.3389/fendo.2017.00286.
Kim, T., and M. A. Lawson, (2015) "GnRH regulates gonadotropin gene expression through NADPH/Dual Oxidase-derived reactive oxygen species." Endocrinology 156 (6): 2185-2199. PDF
Cook-Andersen, H., S. S. Chuan, K. Maas, M.A. Rosencrantz, H. I. Su, M. A. Lawson, H.D. Mason, and R. J. Chang, (2015) "Lack of serum anti-Mullerian Hormone responses following recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome." J. Clin. Endocrinol. Metab.  100 (1): 251–257. PDF
Chen, B., D. P. Siderovski, R. R. Neubig, M. A. Lawson, and JoAnn Trejo. (2014). “Regulation of protease-activated receptor-1 signaling by the adaptor protein complex-2 and R4 subfamily of regulator of G protein signaling proteins” J. Biol. Chem.  289 (3): 1580-1591. PDF
T. Kim, M. T. Do, M. M. A. Lawson. (2014). “Translational control in the gonadotrope”. Mol. Cell. Endocrinology. 385 (1-2): 78-87. PDF
Do, M.T., T. Kim, F. He, H. Dave, U. A. Astorga, R. E. Intriago, S. Jain, and M. A. Lawson. (2014) “Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling”. Mol. Cell. Endocrinology. 382 (1):1346-1357. PDF
Lawson, M.  (2013) “Meeting the challenge to train the next generation of endocrinologists:  filling, diversifying, and plugging leaks in the pipeline.”  Endocrinology 154 (8): 2581-2585. PDF
Terasaka, T., F. Otsuka, N. Tsukamoto, E. Nakamura, K. Inagaki, K. Toma, K. Ogura-Ochia, C. Glidewell-Kenney, M. A. Lawson, H. Makino. (2013)  “Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation in GT1-7 cells.” Mol. Cell. Endocrinol. 381 (1): 8-15. PDF
Park, S.-J., T.-S. Kim, C.-K. Park, S.-H. Lee, K.-S. Lee, I.-K. Lee, J.-W. Park, M. A. Lawson, and D-S. Lee. (2013) hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis.  J. Mol. Endocrinol. 50 (2): 151-166. PDF
Takeda, M., F. Otsuka, H. Takahashi, K. Inagaki, T. Miyoshi, N. Tsukamoto, H. Makino, and M. A. Lawson (2012). “Interaction between Gonadotropin-Releasing Hormone and Bone Morphogenetic Protein-6 and –7 Signaling in LβT2 Gonadotrope Cells.” Mol. Cell. Endocrinol. 348 (1): 146-154. PDF
Mistry, D S., R. Tsutsumi, M. Fernandez, S. Sharma, S. A. Cardenas, M. A. Lawson, and N. J. G. Webster. (2011). “Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-gene is mediated by differential expression of positive regulatory activator protein factors and co-repressors SKIL and TGIF1”. Mol. Endocrinol. 25 (8): 1387-1403. PDF
Nguyen, K. A., R. E. Intriago, H. C. Upadhyay, S. J. Santos, N. J. G. Webster, and M. A. Lawson. (2010) “Modulation of GnRH-Induced ERK Activation by Dual Specificity Protein Phosphatase 1 in LβT2 Gonadotropes”. Endocrinology 151 (10): 4882-4893. PDF
Park, A. S. M. A. Lawson, S. S. Chuan, S. E. Oberfield, K. M. Hoeger, S. F. Witchell, and R. J. Chang. (2010). “Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism.”  J. Clin. Endocrinol. Metab. 95 (4):  1786-1792. PDF
Otani, H., F. Otsuka, M. Takeda, T. Mukai, T. Terasaka, T. Miyoshi, K. Inagaki, J. Suzuki, T. Ogura, M. A. Lawson, and H. Makino. (2009). “Regulation of gonadotropin-releasing hormone production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells.” J. Endocrinol. 203 (1):  87-97. PDF
Navratil, A. M., H. Song, J. B. Hernandez, B. D. Cherrington, S. J. Santos, J. M. Low, M. T. Do, and M. A. Lawson. (2009). Insulin augments gonadotropin releasing hormone induction of translation in LbetaT2 cells.”  Mol. Cell. Endocrinol. 311 (1-2):  47-54. PDF
Do, M. T., S. Santos, and M. A. Lawson. (2009). GnRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line”. Mol. Endocrinol., 23 (1): 100-112. PDF
Feng, J., M. A. Lawson, P. Melamed. (2008). “A proteomic comparison of immature and mature gonadotropes reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Biol. Reprod. 79: 546–561. PDF
Lawson, M.A., S. Jain, S. Sun, K. Patel, P. J. Malcolm, R. J. Chang. (2008). “Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women”.  J. Clin. Endocrinol. Metab, 93 (6): 2089-2096. PDF
Lawson, M. A., R. Tsutsumi, H. Zhang, I. Talukadar, B. K. Butler, S. J. Santos, P. M. Mellon, and N. J. G. Webster. (2007). "Pulse sensitivity of the LHβ promoter is determined by a negative feedback loop involving Egr1 and Nab 1/2.” Mol. Endocrinol., 21 (5):1175–1191. PDF
Zhang, H., J. S. Bailey, D. Coss, B. Lin, R. Tsutsumi, M. A. Lawson, P. L. Mellon and N. J. Webster. (2006). "Activin modulates the transcriptional response of LβT2 cells to GnRH and alters cellular proliferation." Mol. Endocrinol. 20 (11): 2909-2930. PDF
Nguyen, K. A., S. J. Santos, M. K. Kreidel, A. L. Diaz, R. Rey and M. A. Lawson. (2004). "Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LβT2." Mol. Endocrinol. 18 (5): 1301-1312. PDF
Patel, K., M. S. Coffler, M. H. Dahan, R. Y. Yoo, M. A. Lawson, P. J. Malcom and R. J. Chang. (2003). "Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion." J. Clin. Endocrinol. Metab. 88 (11): 5456-5461. PDF
Vasilyev, V. V., M. A. Lawson, D. DiPaolo, N. J. G. Webster and P. L. Mellon. (2002). "Different signaling pathways control acute induction versus long-term repression of LHβ transcription by GnRH." Endocrinology 143 (9): 3414-1426. PDF
Liu, S., K. M. Ogilvie, K. Klausing, M. A. Lawson, D. Jolley, D. Li, J. Bilakovics, B. Pascual, N. Hein, M. Urcan and M. D. Leibowitz. (2002). "Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat." Endocrinology 143 (8): 2880-2885. PDF
Lawson, M. A., L. A. MacConell, J. Kim, B. T. Powl, S. B. Nelson and P. L. Mellon. (2002). "Neuron-specific expression in vivo by defined transcription regulatory elements of the gonadotropin-releasing hormone gene." Endocrinology 143 (4): 1404-1412. PDF
Lawson, M. A. and P. L. Mellon.  (2002). GnRH gene expression:  lessons learned from immortalized cells. In:  Neuroplasticity, development, and steroid hormone action. R.J. Handa (ed.).  CRC Press, Boca Raton, LA.  141-151. PDF
Lawson, M. A., D. Li, C. A. Glidewell-Kenney and F. J. Lopez. (2001). "Androgen responsiveness of the pituitary gonadotrope cell line LbetaT2." J. Endocrinol. 170 (3): 601-607. PDF
Sosnowski, R., P. L. Mellon and M. A. Lawson. (2000). "Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone." Mol. Endocrinol. 14 (11): 1811-1819. PDF
Lopez, F. J., P. D. Finn, M.A. Lawson, and A. Negro-Vilar.  (2000). Regulation of the hypothalamic-pituitary-gonadal axis:  role of gonadal steroids and implications for the menopause In:  Menopause.  R. Lobo, R. Marcus, and J Kelsey. (eds.). Academic Press, San Diego.  Academic Press, San Diego.  33-60. PDF
Nelson, S. B., M. A. Lawson, C. G. Kelley and P. L. Mellon. (2000). "Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells." Mol. Endocrinol. 14 (9): 1509-1522. PDF

Workforce Diversity

Dr. Lawson's commentary in the journal Endocrinology discussing the challenges in training and diversifying the next generation of biomedical scientists.  The Endocrine Society is active in addressing the pressing issues that coincide with the ageing and changing demographics of the U.S.  

Download Link >

Page 'Breadcrumb' Navigation:

External Resources: