Lawson Laboratory In the Department of Obstetrics, Gynecology, and Reproductive Sciences

Lawson Lab Publications

Here is a list of our research publications. Journal links take you to the on line version of the publications.  Click PDF links to download the PDF file.

Androgen Pulse Supression Androgen suppresses in vivo and in vitro LH pulse secretion and neural Kiss1 and Tac2 gene expression in female mice. (2020) Esparza, L.A., T. Terasaka, M.A. Lawson and A.S. Kauffman. Endocrinology, bqaa191, .
MBoC Cover Scientific societies fostering inclusivity through speaker diversity in annual meeting programming: a call to action. (2020) Segarra, V. A. C. Primus, G.A. Unguez, A.Edwards, C. Etson, S.C. Flores, C. Fry, A.N. Guillory, S. L. Ingram, M. Lawson, R. McGee, S. Paxson, L. Phelan, K. Suggs, L.R. Vega, E. Vuong, J.C. Havran, A. Leon, M.D. Burton, J.L. Lujan, M. Ramirez-Alvarado. Molecular Biology of the Cell, Nov 1;31(23):2495-2501. doi: 10.1091/mbc.E20-06-0381.
Sorted Gonadotropes GLUT1-mediated glycolysis supports GnRH-induced secretion of luteinizing hormone from female gonadotropes. (2020) Nicholas, D.A., V.S. Knight, K.J. Tonsfeldt, T. Terasaka, O. Molinar-Inglis, S.B.Z. Stephens, J. Trejo, A.S. Kauffman, P.L. Mellon, and M.A. Lawson.  (2020).    Scientific Reports 10, 13063 (2020).
CBE-LSE Cropped Scientific Societies Fostering Inclusive Scientific Environments through Travel Awards: Current Practices and Recommendations. (2020) Segarra, V.A. L.R. Vega, C. Primus, C. Etson, A.N. Guillory, A. Edwards, S.C. Flores, C. Fry, S.L. Ingram, M. Lawson, R. McGee, S. Paxson L. Phelan, K. Suggs E. Vuong, L. Hammonds-Odie, M. J. Leibowitz, MariaElena Zavala, J. L. Lujan, and M. Ramirez-Alvarado.  CBE-Life Sciences Education 19 (2) es3 pp1-10.
ROS Intensity SRXN1 is Necessary for Resolution of GnRH-Induced Oxidative Stress and Induction of Gonadotropin Gene Expression. Kim, T., D. Li, T. Terasaka, D. A. Nicholas, V.S. Knight, J. J. Yang, and M.A. Lawson. (2019) Endocrinology, 160 (11) pp. 2543-2555. 
ELAVL1 Turnover The RNA-binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH. (2019) Terasaka, T., T. Kim, H. Dave; B. Gangapurkar, D.A. Nicholas, O, Munoz, E. Terasaka, D. Li, and M. A. Lawson.   Endocrinology,160 (8) pp.1999-2014

*Selected for commentary:
ELAVL1 Elevates Insights: The Ups and Downs of Regulated mRNA Translation in the Control of Gonadotropin Release. (2019). A. M. MacNicol, A. Odle, and G. V. Childs, Endocrinology, 160 (10) pp. 2466–2468.
2019-Homer Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome. (2019) Homer, M.V., T. Toloubeydokhti, M. A. Lawson, G. Garzo, A. J. Duleba, and R. J. Chang. (2019). .  Journal of the Endocrine Society, 3 (4), pp 687–698.
2018-Li Induction of stress signaling in vitro and suppression of gonadotropin secretion by free fatty acids in female mouse gonadotropes. (2018) Li, S., E. F. Mbong, D. T. John, T. Terasaka, D. Li, and M. A. Lawson (2018). "" Endocrinology  159 (2):1074-1087.

* Selected for the  Endocrine Society Thematic Issue on Neuroendocrinology.
Terasaka Fig1 Reactive oxygen species link gonadotropin-releasing hormone receptor signaling cascades in the gonadotrope.(2017) Terasaka, T., M. E. Adakama , S. Li, T. Kim, E. Terasaka, D. Li, and M. A. Lawson (2017) "" Front. Endocrinol. 8:286. doi: 10.3389/fendo.2017.00286.
GnRH regulates gonadotropin gene expression through NADPH/Dual Oxidase-derived reactive oxygen species. (2015) Kim, T., and M. A. Lawson, (2015) "" Endocrinology 156 (6): 2185-2199.
Lack of serum anti-Mullerian Hormone responses following recombinant human chorionic gonadotropin stimulation in women with polycystic ovary syndrome. (2015) Cook-Andersen, H., S. S. Chuan, K. Maas, M.A. Rosencrantz, H. I. Su, M. A. Lawson, H.D. Mason, and R. J. Chang. J. Clin. Endocrinol. Metab.  100 (1): 251–257. PDF
Regulation of protease-activated receptor-1 signaling by the adaptor protein complex-2 and R4 subfamily of regulator of G protein signaling proteins. (2014) Chen, B., D. P. Siderovski, R. R. Neubig, M. A. Lawson, and JoAnn Trejo. J. Biol. Chem.  289 (3): 1580-1591. PDF
Translational control in the gonadotrope. (2014) T. Kim, M. T. Do, M. M. A. Lawson. . Mol. Cell. Endocrinology. 385 (1-2): 78-87. PDF
Polyribosome and ribonucleoprotein complex redistribution of mRNA induced by GnRH involves both EIF2AK3 and MAPK signaling. (2014) Do, M.T., T. Kim, F. He, H. Dave, U. A. Astorga, R. E. Intriago, S. Jain, and M. A. Lawson. Mol. Cell. Endocrinology. 382 (1):1346-1357. PDF
Meeting the challenge to train the next generation of endocrinologists: filling, diversifying, and plugging leaks in the pipeline.Lawson, M.(2013)   Endocrinology 154 (8): 2581-2585. PDF
Mutual interaction of kisspeptin, estrogen and bone morphogenetic protein-4 activity in GnRH regulation in GT1-7 cells. (2013) Terasaka, T., F. Otsuka, N. Tsukamoto, E. Nakamura, K. Inagaki, K. Toma, K. Ogura-Ochia, C. Glidewell-Kenney, M. A. Lawson, H. Makino. Mol. Cell. Endocrinol. 381 (1): 8-15. PDF
hCG-induced endoplasmic reticulum stress triggers apoptosis and reduces steroidogenic enzyme expression through activating transcription factor 6 in Leydig cells of the testis. (2013) Park, S.-J., T.-S. Kim, C.-K. Park, S.-H. Lee, K.-S. Lee, I.-K. Lee, J.-W. Park, M. A. Lawson, and D-S. Lee. J. Mol. Endocrinol. 50 (2): 151-166. PDF
Interaction between Gonadotropin-Releasing Hormone and Bone Morphogenetic Protein-6 and –7 Signaling in LβT2 Gonadotrope Cells. (2012) Takeda, M., F. Otsuka, H. Takahashi, K. Inagaki, T. Miyoshi, N. Tsukamoto, H. Makino, and M. A. Lawson Mol. Cell. Endocrinol. 348 (1): 146-154. PDF
Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-gene is mediated by differential expression of positive regulatory activator protein factors and co-repressors SKIL and TGIF1. (2011) Mistry, D S., R. Tsutsumi, M. Fernandez, S. Sharma, S. A. Cardenas, M. A. Lawson, and N. J. G. Webster. (2011). . Mol. Endocrinol. 25 (8): 1387-1403. PDF
Modulation of GnRH-Induced ERK Activation by Dual Specificity Protein Phosphatase 1 in LβT2 Gonadotropes. (2010) Nguyen, K. A., R. E. Intriago, H. C. Upadhyay, S. J. Santos, N. J. G. Webster, and M. A. Lawson. Endocrinology 151 (10): 4882-4893. PDF
Serum anti-mullerian hormone concentrations are elevated in oligomenorrheic girls without evidence of hyperandrogenism. (2010) Park, A. S. M. A. Lawson, S. S. Chuan, S. E. Oberfield, K. M. Hoeger, S. F. Witchell, and R. J. Chang. J. Clin. Endocrinol. Metab. 95 (4):  1786-1792. PDF
Regulation of gonadotropin-releasing hormone production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells. (2009) Otani, H., F. Otsuka, M. Takeda, T. Mukai, T. Terasaka, T. Miyoshi, K. Inagaki, J. Suzuki, T. Ogura, M. A. Lawson, and H. Makino.J. Endocrinol. 203 (1):  87-97. PDF
Insulin augments gonadotropin releasing hormone induction of translation in LbetaT2 cells. (2009) Navratil, A. M., H. Song, J. B. Hernandez, B. D. Cherrington, S. J. Santos, J. M. Low, M. T. Do, and M. A. Lawson.Mol. Cell. Endocrinol. 311 (1-2):  47-54. PDF
GnRH induces the unfolded protein response in the LbetaT2 pituitary gonadotrope cell line. (2009) Do, M. T., S. Santos, and M. A. Lawson. Mol. Endocrinol., 23 (1): 100-112. PDF
A proteomic comparison of immature and mature gonadotropes reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. (2008) Feng, J., M. A. Lawson, P. Melamed.Biol. Reprod. 79: 546–561. PDF
Evidence for insulin suppression of baseline luteinizing hormone in women with polycystic ovarian syndrome and normal women. (2008) Lawson, M.A., S. Jain, S. Sun, K. Patel, P. J. Malcolm, R. J. Chang. (2008).J. Clin. Endocrinol. Metab, 93 (6): 2089-2096. PDF
Pulse sensitivity of the LHβ promoter is determined by a negative feedback loop involving Egr1 and Nab 1/2.(2007) Lawson, M. A., R. Tsutsumi, H. Zhang, I. Talukadar, B. K. Butler, S. J. Santos, P. M. Mellon, and N. J. G. Webster.Mol. Endocrinol., 21 (5):1175–1191. PDF
Activin modulates the transcriptional response of LβT2 cells to GnRH and alters cellular proliferation. (2006) Zhang, H., J. S. Bailey, D. Coss, B. Lin, R. Tsutsumi, M. A. Lawson, P. L. Mellon and N. J. Webster. Mol. Endocrinol. 20 (11): 2909-2930. PDF
Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LβT2. (2004) Nguyen, K. A., S. J. Santos, M. K. Kreidel, A. L. Diaz, R. Rey and M. A. Lawson.Mol. Endocrinol. 18 (5): 1301-1312. PDF
Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. (2003) Patel, K., M. S. Coffler, M. H. Dahan, R. Y. Yoo, M. A. Lawson, P. J. Malcom and R. J. Chang.J. Clin. Endocrinol. Metab. 88 (11): 5456-5461. PDF
Different signaling pathways control acute induction versus long-term repression of LHβ transcription by GnRH. (2002) Vasilyev, V. V., M. A. Lawson, D. DiPaolo, N. J. G. Webster and P. L. Mellon.Endocrinology 143 (9): 3414-1426. PDF
Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat. (2002) Liu, S., K. M. Ogilvie, K. Klausing, M. A. Lawson, D. Jolley, D. Li, J. Bilakovics, B. Pascual, N. Hein, M. Urcan and M. D. Leibowitz. Endocrinology 143 (8): 2880-2885. PDF
Neuron-specific expression in vivo by defined transcription regulatory elements of the gonadotropin-releasing hormone gene. (2002)Lawson, M. A., L. A. MacConell, J. Kim, B. T. Powl, S. B. Nelson and P. L. Mellon.Endocrinology 143 (4): 1404-1412. PDF
GnRH gene expression: lessons learned from immortalized cells. (2002) Lawson, M. A. and P. L. Mellon. In: Neuroplasticity, development, and steroid hormone action. R.J. Handa (ed.)CRC Press, Boca Raton, LA. 141-151. PDF
Androgen responsiveness of the pituitary gonadotrope cell line LbetaT2. (2001) Lawson, M. A., D. Li, C. A. Glidewell-Kenney and F. J. Lopez.J. Endocrinol. 170 (3): 601-607. PDF
Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. (2000) Sosnowski, R., P. L. Mellon and M. A. Lawson. Mol. Endocrinol. 14 (11): 1811-1819. PDF
Regulation of the hypothalamic-pituitary-gonadal axis: role of gonadal steroids and implications for the menopause. (2000) Lopez, F. J., P. D. Finn, M.A. Lawson, and A. Negro-Vilar. In: Menopause. R. Lobo, R. Marcus, and J Kelsey. (eds.). Academic Press, San Diego. Academic Press, San Diego. 33-60. PDF
Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. (2000) Nelson, S. B., M. A. Lawson, C. G. Kelley and P. L. Mellon.Mol. Endocrinol. 14 (9): 1509-1522. PDF
 CBE-LSE Cover

STEM Diversity

The Alliance to Catalyze Change for Equity in STEM Success, or ACCESS, is working to create a community in which diversity-focused committees can interact, synergize, share their collective experiences, and have a unified voice on behalf of URM trainees in science, technology, engineering, and mathematics disciplines. In this Essay, ACCESS compares and contrasts the broad approaches that scientific societies in ACCESS use to implement and assess their travel award programs for URM trainees. We also report a set of recommendations, including both short- and long-term outcomes assessment in populations of interest and specialized programmatic activities coupled to travel award programs.  

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