| The Lawson Lab |
05/30/08
Mark A. Lawson, Ph.D.
Associate Professor
of Reproductive Medicine
Division of Reproductive Endocrinology
Ph.D. Biological Sciences
University of California, Irvine
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Telephone: |
(858) 822-4128 |
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Fax: |
(858) 534-1438 |
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E-mail: |
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| Administrative Assistant: | |
| Janine Hales | |
| E-mail: | jhales@ucsd.edu |
| Telephone: | (858) 534-1140 |
| Lab: | |
| Leichtag Biomedical Research Building 332 | |
| Office: | |
| Leichtag Biomedical Research Building 3A13 | |
Welcome to the Lawson Lab
We hope this site will be useful in keeping you up to date on our lab. Please look around and feel free to give us any feedback.
Research Interests
We are investigating the molecular mechanisms of hormone action in the pituitary, with a special emphasis on factors controlling reproductive function. Our primary topic of interest is the control of reproductive hormone synthesis by the neuropeptide Gonadotropin-Releasing Hormone (GnRH).
Current projects focus on three main areas of GnRH action in the pituitary:
We are studying the regulation of protein synthesis and transcription by GnRH in response to various regimes of pulse amplitude and frequency.
We are examining the signaling mechanisms modulating activity of the translational machinery and the mechanisms of mRNA utilization in response to GnRH stimulation.
We are examining the interaction of intracellular signaling by other physiologically important hormones with GnRH signaling.
General Interest Links
Research Opportunities
Lab Specific Links
Recent Publications
Feng, J., M.A. Lawson and P. Melamed. (2008). A Proteomic Comparison of Immature and Mature Gonadotrophs in Mice Reveals Novel Differentially Expressed Nuclear Proteins That Regulate Gonadotropin Gene Transcription and RNA Splicing. Biology of Reproduction (In Press).
Lawson, MA., S. Jain, S. Sun, K. Patel, P.J. Malcolm, R.J. Chang. (2008). Evidence for Insulin Suppression of Baseline Luteinizing Hormone in Women with Polycystic Ovarian Syndrome and Normal Women. Journal of Clinical Endocrinology and Metabolism. In Press.
Lawson, M.A. R. Tsutsumi, H. Zhang, I. Talukdar, B.K. Butler, P.L. Mellon, and N.J.G. Webster (2007). Pulse Sensitivity of the Luteinizing Hormone ß Promoter is Determined by a Negative Feedback Loop Involving Early Growth Response-1 and Ngfi-A Binding Protein 1 and 2. Molecular Endocrinology. 2007( 21): p. 1175-1191.
Zhang, H., J.S. Bailey, D. Coss, B. Lin, R. Tsutsumi, M.A. Lawson, P.L. Mellon, N.J.G. Webster.(2006). Activin modulates the transcriptional response of LbT2 cells to GnRH and alters cellular proliferation. Molecular Endocrinology, 20(11): p. 2909-2930.
Nguyen, K.A., S.J. Santos, M.K. Kreidel, A.L. Diaz, R. Rey, and M.A. Lawson. (2004). Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LbT2. Molecular Endocrinology, 18(5): p. 1301-1312.
Patel, K., M.S. Coffler, M.H.,Dahan, R.Y. Yoo, M.A. Lawson, P.M. Malcom, and R.J. Chang, (2003). Increased luteinizing hormone secretion in women with polycystic ovary syndrome is unaltered by prolonged insulin infusion. Journal of Clinical Endocrinology and Metabolism 88(11): p. 5456-61.
Vasilyev, V.V., M.A. Lawson, D. DiPaolo. N.J.G. Webster, and P.L. Mellon. (2002). Different signaling pathways control acute induction versus long-term repression of LHb transcription by GnRH. Endocrinology 143(9): p. 3414-3426.
Liu, S., K.M. Ogilvie, K. Klausing, M.A. Lawson, D. Jolley, D. Li, J. Bilakovics, B. Pasqual, N. Hein, M. Urcan, and M.D. Liebowitz (2002). Mechanism of selective retinoid x receptor agonist-induced hypothyroidism in the rat. Endocrinology 143(8): p. 2880-2885.
Lawson, M.A. and P.L. Mellon. (2002). GnRH gene expression: lessons learned from immortalized cells. In: Neuroplasticity, development, and steroid hormone action. R.J. Handa (ed.). CRC Press, Boca Raton, LA. p. 141-151.
Lawson, M.A., L.A. MacConell, J.Kim, B.T. Powl, and P.L. Mellon. (2002). Neuron-specific expression in vivo by defined transcription regulatory elements of the gonadotropin-releasing hormone gene. Endocrinology 143(4): p. 1404-1412.
Lawson, M.A., D. Li, C.A. Glidewell-Kenney, and F.J. López. (2001). Androgen responsiveness of the pituitary gonadotrope cell line LbT2. Journal of Endocrinology 170(3): p. 601-607.
Sosnowski, R., P.L. Mellon, and M.A. Lawson. (2000). Activation of translation in pituitary gonadotrope cells by gonadotropin-releasing hormone. Molecular Endocrinology 14(11): p. 1811-19.
López, F.J., P. D. Finn, M. A . Lawson, and A. Negro-Vilar. (2000). Regulation of the hypothalamic-pituitary-gonadal axis: role of gonadal steroids and implications for the menopause In: Menopause. R. Lobo, J. Kelsey, and R. Marcus. (eds.). Academic Press, San Diego. 33-60.
Nelson, S.B., M. A. Lawson, C. G. Kelley, and P. L. Mellon. (2000). Neuron-specific expression of the rat GnRH gene is conferred by interactions of a defined promoter element with the enhancer. Molecular Endocrinology 14(9): 1509-22.