Kauffman Lab Publications
(**For a complete list of publications, search "Kauffman AS" on Pubmed)
Select Research Publications (beginning with most recent; updated summer 2018)
N Di Giorgio, RB Liaw, RA Parra, JA Yang, N Chahal, VA Lux-Lantos, and
AS Kauffman. Estradiol-dependent and -independent stimulation of Kiss1 expression in the amygdala, BNST, and
lateral septum of mice. Endocrinology.
[Accepted, In Press] 2018.
CI Song, J Hughes, MJ Kreisman, RA Parra, DJ Haisenleder, AS Kauffman, and KM Breen. Acute psychosocial stress inhibits LH
pulsatility and Kiss1 neuronal
activation in female mice. Endocrinology.
158: 3716-323, 2017.
Poling, E Luo, and AS Kauffman. Sex
differences in steroid receptor co-expression and circadian-timed activation of
kisspeptin and RFRP-3 neurons may contribute to the sexually dimorphic basis of
the LH surge. Endocrinology. 158: 3565-3578, 2017.
Stephens SBZ, ML Rouse, KP Tolson, RB. Liaw, RA Parra, N
Chahal, and AS Kauffman. Effects of selective deletion of tyrosine
hydroxylase from kisspeptin cells on puberty and reproduction in male and
female mice. eNeuro 4(3) e0150-17,
KP Tolson, C Garcia, I Delgado, N
Marooki, and AS Kauffman. Metabolism and energy expenditure, but not
feeding or glucose tolerance, are impaired in young Kiss1r KO female mice. Endocrinology, 157: 4192-4199. 2016.
SBZ, N Chahal, N Munaganuru, RA Parra, and AS
Kauffman. Estrogen stimulation of Kiss1
expression in the medial amygdala involves estrogen receptor α but not
estrogen receptor β. Endocrinology, 157:4021-4031. 2016.
Luo E, Stephens SBZ, Chiang S, N Munaganuru, AS Kauffman, and KM Breen.
Corticosterone blocks ovarian cyclicity and the LH surge via decreased
kisspeptin neuron activation in female mice.
Stephens SBZ, KP Tolson, ML Rouse, MC
Poling, MK Hashimoto-Partyka,
PL Mellon, and AS Kauffman. Absent progesterone signaling in
kisspeptin neurons disrupts the LH surge and impairs fertility in female mice. Endocrinology, 156: 3091-97. 2015.
Highlighted in News and Views section of the journal
AS Kauffman, VG Thackray, GE Ryan, KP Tolson, CA
Glidewell-Kenney, SJ Semaan, MC Poling, N Iwata, KM Breen, AJ Duleba, E
Stener-Victorin, S Shimasaki, NJ Webster, and PL Mellon. A novel letrozole
model recapitulates both the reproductive and metabolic phenotypes of polycystic
ovary syndrome in female mice. Biology of
Reproduction, 93: 69: 1-12. 2015.
Poling MC and Kauffman AS. Regulation and Function of RFRP-3 (GnIH) neurons during postnatal development. Frontiers in Endocrinology. 2015.
Semaan SJ and AS Kauffman. Daily successive
changes in reproductive gene expression and neuronal activation in the
brains of pubertal female mice. Molecular
and Cellular Endocrinology, 401, 84-97, 2015.
Poling MC, Shieh M, Munaganuru N, Luo E, and AS Kauffman. Examination
of the influence of leptin and acute metabolic challenge on RFRP-3 neurons of mice in
development and adulthood. Neuroendocrinology,
100: 317-333, 2014.
HM, A Tamrazian, A, H Xie, AS Kauffman,
and PL Mellon. Heterozygous Deletion of Ventral Anterior Homeobox (Vax1) Causes
Subfertility in Mice. Endocrinology 155:4043-4053,
Koemeter-Cox A, TW Sherwood, JA Green, RA Steiner,
NF Berbari, BK Yoder, AS Kauffman, PC Monsma, A Brown, CC Askwith, and K
Mykytyn. Primary Cilia Enhance
Kisspeptin Receptor Signaling on Gonadotropin-Releasing Hormone Neurons. PNAS 111: 10335-40. 2014.
KP, Garcia C, Yen S, Simonds S,
Stefanidis A, Lawrence A, Smith JT, and AS Kauffman. Impaired
kisspeptin signaling influences obesity, metabolism, and glucose homeostasis. J Clinical Investigation, 124(7):
Featured in Nature
Reviews Endocrinology, Research Highlights, Sept. 2014.
Kauffman, Y Sun, J Kim, AR Khan, J Shu, and G Neal-Perry. Vasoactive
intestinal peptide modulation of the steroid-induced LH surge involves
kisspeptin signaling in young but not in middle-aged female rats. Endocrinology, 155: 2222-32, 2014.
Giorgio NP, SJ Semaan, J Kim, PV López, B Bettler, C Libertun, VA Lux-Lantos, and AS Kauffman. Impaired GABAB
receptor signaling dramatically
upregulates Kiss1 expression
selectively in non-hypothalamic brain regions of adult but not prepubertal
mice. Endocrinology, 155(3):1033-44, 2014.
Poling MC, Quennell J, Anderson GM, and Kauffman AS. Kisspeptin neurons do not directly signal to RFRP-3 neurons but RFRP-3 may directly modulate a subset of hypothalamic kisspeptin cells in mice. Journal of Neuroendocrinology 25:
Kim J, Tolson KP, Dhamija S, and Kauffman AS.
Developmental GnRH signaling is not required for sexual differentiation of
kisspeptin neurons but is needed for maximal Kiss1 gene expression in adult females. Endocrinology, 154: 3273-83, 2013.
T, Franks J, and Kauffman AS. Analysis of multiple positive feedback
paradigms demonstrates a complete absence of LH surges and GnRH activation in
mice lacking kisspeptin signaling. Biology of Reproduction, 88: 146-154, 2013.
MC, Kim J, Dhamija S, and AS
Kauffman. Development, sex steroid
regulation, and phenotypic characterization of RFamide-Related Peptide (Rfrp) gene expression and RFamide
receptors in the mouse hypothalamus. Endocrinology,
153, 1827-1840, 2012.
Semaan SJ, Dhamija S, Kim J, Ku EC, and AS Kauffman. Assessment of
epigenetic contributions to sexually dimorphic Kiss1 expression in the anteroventral periventricular nucleus of mice.
Endocrinology, 153, 1875-1886, 2012.
Highlighted in Endocrine News, Research Briefs, April 2012.
Poling MC and AS Kauffman.
Sexually-dimorphic testosterone secretion in prenatal and neonatal mice is
independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology, 153: 782-793, 2012.
Highlighted in Endocrine News,
Research Briefs, Feb 2012.