Thackray

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women, with a prevalence of 10-15%.  In addition to a reproductive phenotype that results in an increased risk of infertility, miscarriage and pregnancy complications, a majority of women with PCOS have metabolic abnormalities that result in an increased risk of type 2 diabetes, gestational diabetes and cardiovascular disease. The main objective of our research is to understand the etiology and pathophysiology of PCOS using relevant mouse and tissue culture models.