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​​​​Research Collage


List of Recent Mellon Lab Publications (since 2008)

For a full list of publications, please see MyBibliography​


​Ryan, G. E., Bohaczuk, S. C., Cassin, J., Witham, E. A., Shojaei, S., Ho, E. V., Thackray, V. G., Mellon, P.L. (2021). Androgen Receptor Positively Regulates Gonadotropin-releasing Hormone Receptor in Pituitary Gonadotropes. Molecular and Cellular Endocrinology, In Press.

Bohaczuk, S. C., Cassin, J., Slaiwa, T. I., Thackray, V. G., Mellon, P. L. (2021). Distal Enhancer Potentiates Activin- and GnRH-Induced Transcription of FSHB. Endocrinology 162. in press. PMID: 3382​4966. DOI: 10.1210/endocr/bqab069

​Schoeller E. L.,* Tonsfeldt, K. J.,* Sinkovich, M., Shi, R., Mellon, P. L. (2021). Growth Hormone Pulses and Liver Gene Expression are Differentially Regulated by the Circadian Clock Gene Bmal1. Endocrinology 162(4), 1-16. PMID: 33539533. PMC7901660. *equivalent contributions​

​Bohaczuk, S. C., Thackray V. G., Shen, J., Skowronska-Krawczyk, D., Mellon, P. L. (2020). FSHβ Transcription is Regulated by a Novel 5’ Distal Enhancer with a Fertility-Associated Single Nucleotide Polymorphism. Endocrinology 162(1), 1-12. PMID: 33009549, PMC7846141

​Coré, N., Erni, A., Hoffmann, H. M., Mellon, P. L., Saurin, A. J., Béclin, C., and Cremer, H. (2020). Stem Cell Regionalization During Olfactory Bulb Neurogenesis Depends on Regulatory Interactions between Vax1 and Pax6. eLife 9, e58215. PMID: 32762844; PMC7440913

​Nicholas, D. A., Knight, V. S., Tonsfeldt, K. J., Terasaka, T., Molinar-Inglis, O., Stephens, S. B. Z., Trejo, J., Kauffman, A. S., Mellon, P. L., Lawson, M. A. (2020). GLUT1-mediated Glycolysis Supports GnRH-induced Secretion of Luteinizing Hormone from Female Gonadotropes. Scientific Reports, 10, 13063PMID: 32747664; PMC7400764

Gou, L.-T., Lim, D.-H., Ma, W., Aubol, B. E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., Zhang, X., Meng, F., Li, H., Zhang, X., Xu, R., Li, D., Rosenfeld, M. G., Mellon, P. L., Adams, J. A., Liu, M.-F., Fu, X.-D. (2020). Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine PhosphorylationCell 180(6), 1212-1227. PMID: 3216915; PMC7190278

Pandolfi, E. C., Breuer, J. A., Huu, V. A. N., Talluri, T., Nguyen, D., Lee, J. S., Hu, R., Bharti, K., Skowronska-Krawczyk, D., Gorman, M. R., Mellon, P. L., Hoffmann, H. M. (2019). The Homeodomain Transcription Factors Vax1 and S​ix6 are Required for SCN Development and Function. Molecular Neurobiology 57(2), 1217-1232. PMID:31705443; PMC7035166​ 

Pandolfi, E. C., Tonsfeldt, K. J., Hoffmann, H. M., and Mellon, P. L. (2019). Deletion of the Homeodomain Protein Six6 from GnRH Neurons Decreases GnRH Gene Expression Resulting in Infertility. Endocrinology, 160, 2151-2164     PMID:31211355; PMC6821215    

Ruf-Zamojski, F., Ge, Y., Pincas, H., Shan, J., Song, Y., Hines, N., Kelley, K., Montagna, C., Nair, P., Toufaily, C., Bernard, D. J., Mellon, P. L., Nair, V., Turgeon, J. L., and Sealfon, S. C. (2019). Cytogenetic, Genomic, and Functional Characterization of Pituitary Gonadotrope Cell Lines: Identification of Two LβT2 Lines. Journal of the Endocrine Society 3, 902-920. PMID: 31020055; PMC6469952

Hoffmann, H. M.,* Larder, R.,* Lee, J. S., Hu, R. J., Trang, C., Devries, B. M., Clark, D. D., and Mellon, P. L. (2019). Differential CRE expression in Lhrh-cre and Gnrh-cre alleles and the impact on fertility in Otx2-flox mice. Neuroendocrinology, 108, 328-342. PMID:30739114; PMC6753941 *equivalent contributions

Tonsfeldt, K. J., Schoeller, E. L., Brusman, L. E., Cui, L. J., Lee, J., Mellon, P. L. (2019). The Contribution of the Circadian Gene Bmal1 to Female Fertility and the Generation of the Preovulatory Luteinizing Hormone Surge. Journal of the Endocrine Society 3, 716-733. PMID: 30906911; PMC6425515

Hoffmann, H. M.,* Pandolfi, E. C.,* Larder, R.,* Mellon, P. L.  (2018). Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. Neuroendocrinology, in press. *Co-first authors. (Review Article).  PMID: 30261489; PMC6437011    

Pandolfi, E. C., Hoffmann, H. M., Schoeller, E. L., Gorman, M. R., and Mellon, P. L. (2018). Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior through Disrupted Olfactory Development, and Impairs Female Fertility through Disrupted GnRH Neuron Migration.  Molecular Neurobiology 55, 8709-8727. PMID: 29589282; PMC6156938    

Que, X., Hung, M.-Y., Yeang, C., Gonen, A., Prohaska, T., Sun, X., Diehl, C., Määttä, A., Gaddis, D. E., Bowden, K., Pattison, J., MacDonald, J. G., Ylä-Herttuala, S., Mellon, P. L., Hedrick, C. C., Ley, K., Miller, Y. I., Glass, C. K., Peterson, K. L., Binder, C. J., Tsimikas, S., Witztum, J. L. (2018). Oxidized Phospholipids are Proinflammatory and Proatherogenic in Hypercholesterolemic Mice. Nature 558, 301-306; PMID: 29875409; PMC6033669

Ryan, G. E., Malik, S., Mellon, P. L. (2018). Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-induced Mouse Model of PCOS.  Endocrinology 159, 1734-1747. PMID: 29471436; PMC6097580    

​ Hoffmann, H. M., Gong, P., Tanrazian, A., Mellon, P. L. (2017). Transcriptional Interaction Between cFOS and the Homeodomain-binding Transcription Factor VAX1 on the GnRH Promoter Controls Gnrh1 Expression Levels in a GnRH Neuron Maturation Specific Manner. Molecular and Cellular Endocrinology 461, 143-154 PMID: 28890143; PMC5756504    

Xie, H., Hoffmann, H. M., Iyer, A. K., Brayman, M. J., Ngo, C., Sunshine, M. J., and Mellon, P. L. (2017). Chromatin Status and Transcription Factor Binding to Gonadotropin Promoters in Gonadotrope Cell LinesReproductive Biology and Endocrinology 15, 86. PMID: 29065928; PMC5655979​

Schoeller, E. L., Clark, D. D., Dey, S., Cao, N. V., Semaan, S. J., Chao, L. W., Kauffman, A. S., Stowers, L., Mellon, P. L. (2016). Bmal is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology ​157, 4914-4929. PMID: 27704948, PMC5133342

Huang, P. P., Brusman, L. E., Iyer, A. K., Webster, N. J. G., Mellon, P. L. (2016). A Novel Gonadotropin-Releasing Hormone 1 (GnRH1) Enhancer-Derived Noncoding RNA Regulates GnRH1 Gene Expression in GnRH Cell Models. PlosOne 11(7):e0158597.​  PMID: 27389022, PMC4936741

  Hoffmann, H. M., Trang, C., Gong, P., Kimura, I., Pandolfi, E. C., and Mellon, P. L. (2016). Deletion of Vax1 from GnRH Neurons Abolishes GnRH Expression and Leads to Hypo​gonadism and Infertility. Journal of Neuroscience 36, 3506-3518.​ PMID: 27013679 PMC4804008​

Skowronska-Krawczyk, D., Zhao, L., Zhu, J., Weinreb, R. N., Cao, G., Luo, J., Flagg, K., Patel, S., Wen, C., Krupa, M., Luo, H., Ouyang, H., Lin, D., Wang, W., Li, G., Xu, Y., Li, O., Chung, C., Yeh, E., Jafari, M., Ai, M., Zhong, Z., Shi, W., Zheng, L., Krawczyk, M., Chen, D., Shi, C., Zin, C., Zhu, J., Mellon, P. L., Gao, W., Abagyan, R., Zhang, L., Sun, X., Zhong, S., Zhuo, Y., Rosenfeld, M. G., Liu, Y., Zhang, K. (2015). P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Molecular Cell 59, 931-940. PMID: 26365380, PMC4648709

Kauffman, A. S., Thackray, V. G., Ryan, G. E., Tolson, K. P., Glidewell-Kenney, C. A., Seeman, S. J., Poling, M. C., Iwata, N., Breen, K. M., Duleba, A. J., Stener-Victorin, E., Shimasaki, S., Webster, N. J., and Mellon, P. L. (2015). A Novel Letrozole Mouse Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice.  Biology of Reproduction 93(3):69, 1-12. PMID: 26203175, PMC4710190    

Stephens, S. B, Tolson, K. P., Rouse, M. L., Poling, M. C., Hashimoto-Partyka, M. K., Mellon, P. L., Kauffman, A. S. (2015). Absent Progesterone Signaling in Kisspeptin Neurons Disrupts the LH Surge and Impairs Fertility in Female Mice. Endocrinology 156, 3091–3097.   PMID: 26076042,  PMC4541622    

Xie, H., Hoffmann,* H. M., Meadows,* J. D., Mayo, S. L., Trang, C., Leming, S., Maruggi, C., Davis, S. W., Larder, R., and Mellon, P. L. (2015). Homeodomain Proteins Six6 and Six3 Regulate Gonadotrope-specific Genes During Pituitary Development. Molecular Endocrinology 29, 842-855. *Co-second author. PMID: 25915183, PMC4447639

Ahow,* M., Min,* L., Pampillo, M., Nash, C., Wen, J., Soltis, K., Carroll, R. S., Glidewell-Kenney, C. A., Mellon, P. L., Bhattacharya, M., Tobet, S. A., Kaiser,# U. B., Babwah,# A. V. (2014). KISS1R Signals Independently of Gαq/11 and Triggers LH Secretion Via the β-arrestin Pathway in the Male Mouse. Endocrinology 155, 4433-4446. *Co-first author; #Co-Senior author. PMID: 25105693, PMC4197989     
Roybal, L. L., Hambarchyan, A., Meadows, J. D., Barakat, N. H., Pepa, P. A., Breen, K. M., Mellon, P. L., and Coss, D. (2014). Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. Molecular Endocrinology 28, 1640-1655. PMID: 25105693, PMC4179627 
Hoffmann, H. M., Tamrazian, A., Xie, H., Pérez-Millán, M. I., Kauffman, A. S., and Mellon, P. L. (2014). Heterozygous Deletion of Ventral Anterior Homeobox (Vax1) Causes Subfertility in Mice. Endocrinology 155, 4043–4053. PMID 25060364, PMC4164932
Glidewell-Kenney, C. A., Trang, C., Shao, P. P., Guteirrez-Reed, N., Uzo-Okereke, A. M., Coss, D., Mellon, P.L. (2014). Neurokinin B Induces c-fos Transcription via Protein Kinase C and Activation 1 of Serum Response Factor and Elk-1 in Immortalized GnRH Neurons.  Molecular Endocrinology 27, 437-454. PMID 23393128, PMC3589675     
Witham, E. A., Meadows, J. D., Hoffmann, H. M., Shojaei, S., Coss, D., Kauffman, A. S., and Mellon, P. L. (2013). Kisspeptin Regulates Gonadotropin Genes Via Immediate Early Gene Induction in Pituitary Gonadotropes. Molecular Endocrinology 27, 1283-1294. PMID 23770611, PMC3725344    ​

Larder, R., Kimura, I., Meadows, J. D., Clark, D. D., Mayo, S., and Mellon, P. L. (2013). Gene Dosage of Otx2 is Important for Fertility in Male Mice. Molecular Cellular Endocrinology 377, 16-22. PMID 23811236, PMC3771655   
Glidewell-Kenney, C. A., Shao, P. P., Iyer, A. K., Grove, A. M. H., Meadows, J. D., and Mellon, P. L. (2013). Neurokinin B Causes Acute GnRH Secretion and Long-term Repression of GnRH Transcription in GT1-7 GnRH Neurons. Molecular Endocrinology 27, 437-454. PMID 23393128, PMC3589675    ​

Xie, H., Cherrington, B. D, Meadows, J. D., Witham, E. A., and Mellon, P. L. (2013). The Homeodomain Protein, Msx1, Represses the αGSU and GnRH Receptor Genes During Gonadotrope Development. Molecular Endocrinology 27, 422-436. PMID 23371388, PMC3589667    

Clark, D. D., Gorman, M. R., Hatori, M., Meadows, J. D., Panda, S., and Mellon, P. L. (2013). Aberrant Development of the Suprachiasmatic Nucleus and Circadian Rhythms in Mice Lacking the Homeodomain Protein Six6. Journal of Biological Rhythms 28, 15-25. PMID 23382588, PMC3586279 
Brayman, M. J., Pepa, P. A., and Mellon, P. L. (2012). Androgen Receptor Repression of Gonadotropin-Releasing Hormone Gene Transcription Via Enhancer 1. Molecular Cellular Endocrinology 363, 92-99. PMID 22877652, PMC3447085    

Breen, K. M., Thackray, V. G., Hsu, T., Mak-McCully, R., Coss, D., and Mellon P. L. (2012). Stress Levels of Glucocorticoids Inhibit LHβ Subunit Gene Expression in Gonadotrope Cells. Molecular Endocrinology 26, 1716-1731. PMID 22851703, PMC3458227    ​

Witham, E. A., Meadows*, J. D., Shojaei*, S., Kauffman, A. S., and Mellon, P. L. (2012). Prenatal Exposure to Low Levels of Androgen Accelerates Female Puberty Onset and Reproductive Senescence in Mice. Endocrinology 153: 4522-4532. *equivalent contributions. PMID 22778229, PMC3423623    

Ghochani, Y., Saini, J. K., Mellon, P. L., and Thackray, V. G. (2012). FoxL2 Is Involved in the Synergy between Activin and Progestins on the Follicle-Stimulating Hormone β-Subunit Promoter. Endocrinology 153, 2023-2033. PMID 22294749, PMC3320250

Brayman, M. J., Pepa, P. A., Berdy, S. E., and Mellon, P. L. (2012). Androgen Receptor Repression of GnRH Gene Transcription. Molecular Endocrinology 26, 2-13. PMID 22074952, PMC3248321

Lan, D., Lu, M., Sharma, S., Mellon, P. L., Olefsky, J. M., and Webster, N. J. G. (2011). Trans-Resveratrol Inhibits Phosphorylation of Smad2/3 and Represses FSHβ Gene Expression by a SirT1-Independent Pathway in LβT2 Gonadotrope Cells. Reproductive Toxicology 32, 85-92. Description: clearPMID 21679764, PMC3155991

Beneduzzi, D., Iyer, A. K., Trarbach, E. B., Silveira-Neto, A. P., Silveira, L. G., Tusset, C., Yip, K., Mendonça, B. B., Mellon, P. L., and Latronico, A. C. (2011). Mutational Analysis of the Necdin Gene in Patients with Congenital Isolated Hypogonadotropic Hypogonadism. European Journal of Endocrinology 165, 145-150. PMID 21543378, PMC3203643

Yueh, M. F., Mellon, P. L., and Tukey, R. H. (2011). Inhibition of Human UGT2B7 Gene Expression in Transgenic Mice by the Constitutive Androstane Receptor. Molecular Pharmacology 79, 1053-1060. PMID 21415305, PMC3102552    ​

Ely, H. A., Mellon, P. L., and Coss, D. (2011). GnRH Induces the c-Fos Gene via Phosphorylation of SRF by the Calcium/Calmodulin Kinase II Pathway. Molecular Endocrinology 25, 669-680. PMID 21292826, PMC3063085

Iyer, A. K., Brayman, M. J., and Mellon, P. L. (2011). Dynamic Chromatin Modifications Control GnRH Gene Expression during Neuronal Differentiation and Protein Kinase C Signal Transduction. Molecular Endocrinology 25, 460-473. PMID 21239613, PMC3045737

Larder, R., Clark, D. D., Miller, N. L. G., and Mellon, P. L. (2011). Hypothalamic Dysregulation and Infertility in Mice Lacking the Homeodomain Protein Six6. The Journal of Neuroscience 31, 426-438. PMID 21228153, PMC3103738

Sharma, S., Sharma, P. M., Mistry, D. S., Chang, R. J., Olefsky, J. M., Mellon, P. L., and Webster, N. J. G. (2011). PPARg Regulates Gonadotropin-Releasing Hormone Signaling in LβT2 Cells In Vitro and Pituitary Gonadotrope Function In Vivo in Mice. Biology of Reproduction 84, 466-475. PMID 21076077, PMC3043129    ​

Iyer, A. K., Miller, N. L. G., Yip, K., Tran, B. H., and Mellon, P. L. (2010). Enhancers of GnRH Transcription Embedded in an Upstream Gene Utilize Homeodomain Proteins to Specify Hypothalamic Expression. Molecular Endocrinology 24, 1949-1964. PMID 20667983; PMC2954641    
Breen, K. M., Thackray, V. G., Coss, D. and Mellon, P. L. (2010). Runt-Related Transcription Factors Impair Activin Induction of the Follicle-Stimulating Hormone b-Subunit Gene. Endocrinology 151, 2669-2680. PMID 20357224; PMC2875819

Corpuz, P. S., Lindaman, L. L., Mellon, P. L., and Coss, D. (2010). FoxL2 is Required for Activin Induction of the Mouse and Human Follicle-Stimulating Hormone β-Subunit Genes. Molecular Endocrinology 24, 1037-1051. PMID 20233786; PMC2870942    

Larder, R. and Mellon, P. L. (2009). Otx2 Induction of the Gonadotropin-Releasing Hormone Promoter is Modulated by Direct Interactions with Grg Co-Repressors. The Journal of Biological Chemistry 284, 16966-16978. PMID 19401468; PMC2719334

Thackray, V. G., Hunnicutt, J. L., Memon, A. K., Ghochani, Y., and Mellon, P. L. (2009). Progesterone Inhibits Basal and Gonadotropin-Releasing Hormone Induction of Luteinizing Hormone β-Subunit Gene Expression. Endocrinology 150, 2395-2403. PMID 19106225; PMC2671912    
Miller, N. L. G., Wevrick, R., and Mellon, P. L. (2009). Necdin, a Prader-Willi Syndrome Candidate Gene, Regulates Gonadotropin-releasing Hormone Neurons during Development. Human Molecular Genetics 18, 248-260. PMID 18930956; PMC2638776 
Avelino-Cruz, J. E., Flores, A., Cebada, J., Mellon, P. L., Felix, R., and Monjaraz, E. (2009). Leptin Increases L-type Ca2+ Channel Expression and GnRH-stimulated LH Release in LβT2 Gonadotropes. Molecular and Cellular Endocrinology 298, 57-65. PMID 18834922; PMC2659688

Cherrington,* B. D., Bailey,* J. S., Diaz, A. L., and Mellon, P. L. (2008). NeuroD1 and Mash1 Temporally Regulate GnRH Receptor Gene Expression in Immortalized Mouse Gonadotrope Cells. Molecular and Cellular Endocrinology 295, 106-114. *equivalent contributions. PMID 18760324; PMC2640340   
Sasson,* R., Luu,* S. H., Thackray, V. G., and Mellon, P. L. (2008). Glucocorticoids Induce Human Glycoprotein Hormone Alpha-Subunit Gene Expression in the Gonadotrope. Endocrinology 149, 3643-3655. *equivalent contributions. PMID 18403486; PMC2453092    
Thackray, V. G., and Mellon, P. L. (2008). Synergistic Induction of Follicle-Stimulating Hormone β-subunit Gene Expression by Gonadal Steroid Hormone Receptors and Smad Proteins. Endocrinology 149, 1091-1102. PMID 18079204; PMC2275352

McMahon, H. E., Hashimoto, O., Mellon, P. L., and Shimasaki, S. (2008). Oocyte-specific Overexpression of Mouse Bone Morphogenetic Protein-15 Leads to Accelerated Folliculogenesis and an Early Onset of Acyclicity in Transgenic Mice. Endocrinology 149, 2807-2815. PMID 18308851; PMC2408818    ​

Lu, M., Tang, Q., Olefsky, J. M., Mellon, P. L., and Webster, N. J. G. (2008). Adiponectin Activates Adenosine Monophosphate-activated Protein Kinase and Decreases Luteinizing Hormone Secretion in LβT2 Gonadotropes. Molecular Endocrinology 22, 760-771. PMID 18006641; PMC2262174 ​