 |
Ma H, Morey R, O’Neil RC, He Y,
Daughtry B, Schultz MD, Hariharan M, Nery JR, Castanon
R, Sabatini K, Thiagarajan RD, Tachibana M, Kang E,
Tippner-Hedges R, Ahmed R, Gutierrez NM, Van Dyken C,
Polat A, Sugawara A, Sparman M, Gokhale S, Amato P, Wolf
DP, Ecker JR*, Laurent LC*, Mitalipov
S*. 2014. “Abnormalities in human pluripotent cells due
to reprogramming mechanisms.” Nature, Epub ahead of
print. *Co-corresponding authors. |
|
Wolfe LM, Thiagarajan RD,
Boscolo F, Tache V, Coleman RL, Kim J, Kwan WK, Loring
JF, Parast M, Laurent LC. 2014.
“Banking Placental Tissue: An Optimized Collection
Procedure for Genome-Wide Analysis of Nucleic Acids.”
Placenta, Epub ahead of print. |
 |
Ben-Yosef D, Boscolo FS, Amir
H, Malcov M, Amit A, Laurent LC. 2013.
“Genomic Analysis of hESC Pedigrees Identifies De Novo
Mutations and Enables Determination of the Timing and
Origin of Mutational Events.” Cell Reports, 4(6):1-15.
|
 |
Li Y, Moretto-Zita M, Soncin F,
Wakeland A, Wolfe L, Leon-Garcia S, Pandian R, Pizzo D,
Cui L, Nazor K, Loring JF, Crum CP, Laurent LC,
Parast MM. 2013. “BMP4-directed trophoblast
differentiation of human embryonic stem cells is
mediated through a DNp63+ cytotrophoblast stem cell
state.” Development, 140(19):3965-76. |
 |
Liao X, Xue H, Wang Y-C, Nazor
KL, Guo S, Trivedi N, Peterson SE, Liu Y, Loring JF,
Laurent LC. 2013. “Matched miRNA and
mRNA signatures from a hESC-based in vitro model of
pancreatic differentiation reveal novel regulatory
interactions.” Journal of Cell Science, 126:3848-3861.
|
 |
Jones JC, Sabatini K, Liao X,
Tran HT, Lynch CL, Morey RE, Glenn-Pratola V, Boscolo
FS, Yang Q, Parast MM, Liu Y, Peterson SE,
Laurent LC, Loring JF, Wang YC. “Melanocytes
derived from transgene-free human induced pluripotent
stem cells.” Journal of Investigative Dermatology, epub
ahead of print. |
 |
Song HW, Anderson RA, Bayne RA,
Gromoll J, Shimasaki S, Chang RJ, Parast MM,
Laurent LC, de Rooij DG, Hsieh TC, Wilkinson
MF. 2013. “The RHOX homeobox gene cluster is selectively
expressed in human oocytes and male germ cells.” Human
Reproduction, epub ahead of print. |
 |
Kurian L, Sancho-Martinez I,
Nivet E, Moon K, Pendaries C, Volle-Challier C, Bono F,
Herbert J-M, Xia Y, Li M, Pulecio J, Montserrat N, Ruiz
S, Aguirre A, Dubova I, Rodriguez C, Denli AM, Boscolo
FS, Thiagarajan RD, Gage FH, Loring JF, Laurent
LC, Belmonte JCI. 2013. “Conversion of Human
Fibroblasts Into Vascular Cells.” Nat Methods,
10(1):77-83. |
 |
Ramskold D, Luo S, Wang Y-C, Li
R, Deng Q, Daniels GA, Khrebtukova I, Loring JF,
Laurent LC, Schroth GP, Sandberg R. 2012.
“Full-Length mRNA-Seq from Single Cell Levels of RNA and
Individual Circulating Tumor Cells.” Nat Biotechnol,
30(8):777-82. |
 |
Norton ME, Brar H, Weiss J,
Karimi A, Laurent LC, Caughey A,
Rodriguez H, Williams J, Mitchell M, Adair CD, Lee H,
Jacobbson B, Tomlinson MW, Oepkes D, Hollemon D, Sparks
A, Oliphant A, Song K. 2012. “Non-Invasive Chromosomal
Evaluation (NICE) Study: Results of a Multicenter,
Prospective, Cohort Study for Fetal Trisomy Detection.”
Am J Obstet Gynecol, 207(2):137.e1-8. |
 |
Wang W, Feng L,
Zhang H-H, Hachey S, Satohisha S, Laurent LC,
Parast M, Zheng J, Chen D. 2012. “Preeclampsia
upregulates angiogenesis-associated microRNAs (miR-17,
20a and 20b) that target ephrin B2 and EPHB4 in human
placenta.” J Clin End and Met., 97(6):E1051-9. |
 |
Nazor KL, Altun
G, Lynch C, Tran H, Harness JV, Slavin I, Garitaonandia
I, Müller F-J, Wang Y-C, Boscolo FS, Fakunle E, Lee S,
Park HS, Martynova M, Olee T, D'Lima DD, Semechkin R,
Parast M, Galat V, Laslett AL, Schmidt U, Keirstead HS,
Loring JF, Laurent LC. 2012. “Recurrent
Variations in DNA Methylation in Human Pluripotent Stem
Cells and their Differentiated Derivatives.” Cell Stem
Cell, 10(5):620-34. |
 |
Liao W-X,
Laurent L, Agent S, Hodges J, Chen
D-B. 2012. “Human Placental Expression of SLIT/ROBO
Signaling Cues: Effects of Preeclampsia and Hypoxia.”
Biology of Reproduction, 86(4):111. |
|
Ruff D,
Macarthur C, Tran H, Bergseid J, Tian J, Shannon M, Chen
SM, Fontes A, Laurent L, Swartzman E,
Taliana A, Rao M, Lieu P. 2012. “Applications of
Quantitative PCR Protein Assays During Reprogramming.”
Stem Cells and Development, 21(4):530-8. |
 |
MacArthur CC,
Xue H, Van Hoof D, Lieu PT, Dudas M, Fontes A,
Swistowski A, Touboul T, Seerke R, Laurent LC,
Loring JF, German MS, Zeng X, Rao MS, Lakshmipathy U,
Chesnut JD, Liu Y. 2011. “Chromatin Insulator Elements
Block Transgene Silencing in Engineered Human Embryonic
Stem Cell Lines at a Defined Chromosome 13 Locus.” Stem
Cells and Development, 21(2):191-205. |
 |
Israel MA, Yuan
SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van
Gorp S, Marsala M, Nazor KL, Boscolo FS, Laurent
LC, Carson CT, Gage FH, Remes AM, Koo EH,
Goldstein LSB. 2012. “Probing sporadic and familial
Alzheimer's disease using induced pluripotent stem
cells.” Nature, 482:216-220. |
 |
Fan JB, Chen J,
April CS, Fisher JS, Klotzle B, Bibikova M, Kaper F,
Ronaghi M, Linnarsson S, Ota T, Chien J, Laurent
LC, Nisperos SV, Chen GY, Zhong JF. 2012.
“Highly Parallel Genome- Wide Expression Analysis of
Single Mammalian Cells.” PLoSOne, 7(2): e30794. |
 |
Peterson SE,
Tran HT, Garitaonandia I, Han S, Nickey KS, Leonardo T,
Laurent LC, Loring JF. 2011. “Teratoma
Generation in the Testis Capsule.” Journal of
Visualized Experiments, Issue 57. |
 |
Wang Y-C,
Nakagawa M, Garitaonandia I, Slavin I, Altun G,
Lacharite R, Nazor K, Tran H, Lynch C, Leonardo T, Liu
Y, Peterson S, Laurent LC, Yamanaka S,
Loring JF. 2011. “Specific lectin biomarkers for
isolation of human pluripotent stem cells identified
through array-based glycomic analysis.” Cell Research,
21(11):1551-63. |
 |
Ben-Nun IF,
Montague SC, Houck ML, Tran HT, Baritaonandia I,
Leonardo TR, Wang Y-C, Charter SJ, Laurent LC,
Ryder OA, Loring JF. 2011. “Generation of induced
pluripotent stem cells from highly endangered species.”
Nature Methods, 8(10):829-31. |
 |
Golob J, Kumar
R, Guenther M, Pabon L, Pratt GA, Loring JF,
Laurent LC, Young R, Murry CE. 2011. “Evidence
That Gene Activation and Silencing During Stem Cell
Differentiation Requires a Transcriptionally Paused
Intermediate State.” PLoS ONE, 6(8):e22416. |
 |
Peterson SE,
Westra JW, Rehen SK, Young H, Buschman D, Paczkowski CM,
Yung YC, Lynch CL, Tran HT, Nickey KS, Wang Y-C,
Laurent LC, Loring JF, Carpenter MK, Chun J.
2011. “Normal human pluripotent stem cell lines exhibit
pervasive mosaic aneuploidy.” PLoS One, 6(8):e23018. |
 |
Liu G-H, Suzuki
K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet
E, Kim J, Soligalla D, Dubova I, Goebl A, Plongthongkum
N, Fung H-L, Zhang K, Loring JF, Laurent LC,
Belmonte JCI. 2011. “Targeted Gene Correction of
Laminopathy-Associated LMNA Mutations in
Patient-Specific iPSCs.” Cell Stem Cell, 8(6):688-94. |
 |
Muller FJ,
Schuldt BM, Williams R, Mason D, Altun G, Papapetrou E,
Danner S, Goldman JE, Herbst A, Schmidt NO, Aldenhoff
JB, Laurent LC, Loring JF. 2011. “A
bioinformatic open access assay for pluripotency in
human cells.” Nature Methods, 8(4):315-17. |
 |
Harness JV,
Turovets NA, Seiler MJ, Nistor G, Altun G, Agapova LS,
Ferguson D, Laurent LC, Loring JF,
Keirstead HS. 2011. “Equivalence of
Conventionally-Derived and Parthenote-Derived Human
Embryonic Stem Cells.” PlosOne. 6(1):e14499. |
 |
Laurent
LC, Ulitsky I, Slavin I, Tran H, Schork A,
Morey R, Lynch C, Harness JV, Lee S, Barrero MJ, Ku S,
Martynova M, Semechkin R, Galat V, Gottesfeld J,
Belmonte JCI, Murry C, Keirstead HS, Park H-S, Schmidt
U, Laslett AL, Muller F-J, Nievergelt CM, Shamir R,
Loring JF. 2011. “Dynamic Changes in the Copy Number of
Pluripotency and Cell Proliferation Genes in Human ES
and iPS Cells during Reprogramming and Time in
Culture.” Cell Stem Cell. 8(1):106-118. |
 |
Ku S, Soragni E,
Campau E, Thomas EA, Altun G, Laurent L,
Loring JF, Napierala M, Gottesfeld JM. 2010. “Friedreich’s
Ataxia Induced Pluripotent Stem Cells Recapitulate
GAA•TTC Triplet-Repeat Instability.” Cell Stem Cell.
7(5):631-7. |
 |
Ulitsky I,
Laurent LC, Shamir R. 2010. "Towards
Computational Prediction of MicroRNA Function and
Activity." Nucleic Acids Research. 38(15):e160. |
 |
Laurent
LC, Wong E, Li GL, Huynh T, Tsirigos A, Li R,
Zhou G, Ong CT, Low HM, Sun W-K, Rigoutsos I, Wang J,
Loring JF, Wei C-L. 2010. "Dynamic Changes in the
Human Methylome During Differentiation." Genome
Research. 20(3):320-31. |
 |
Abraham S,
Sheridan SD, Laurent LC, Albert K,
Stubban C, Ulitsky I, Miller B, Loring JF, Rao R.
2010. "Propagation of human embryonic and induced
pluripotent stem cells in an indirect co-culture
system." Biochem Biophys Res Commun. 393(2):211-6. |
 |
Laurent
LC, Nievergelt CM, Lynch C, Fakunle E, Harness
J, Schmidt U, Galat V, Laslett AL, Otonkoski T,
Keirstead H, Schork A, Park H-S, Loring JF. 2010.
"Restricted Ethnic Diversity in Human Embryonic Stem
Cells." Nature Methods. 7(1):6-7. |
 |
Muller F-J,
Laurent LC, Kostka D, Ulitsky I,
Williams R, Lu C, Rao MS, Shamir R, Schwartz PH, Schmidt
NO, Loring JF. 2008. “Regulatory networks define
phenotypic classes of human stem cell lines.” Nature.
455:401-405. |
 |
Laurent
LC, Chen J, Ulitsky I, Mueller F-J, Lu C,
Shamir R, Fan J-B, Loring JF. 2008.
“Comprehensive MicroRNA profiling
reveals a unique human embryonic stem cell signature
dominated by a single seed sequence.” Stem Cells,
26:1506-1516. |
 |
Rothenberg SM,
Olsen MN, Laurent LC, Crowley RA, Brown
PO. 2001. “Comprehensive mutational analysis of the
Moloney murine leukemia virus envelope protein.” Journal
of Virology , 75(23):11851-62. |
 |
Laurent
LC, Olsen MN, Crowley RA, Savilahti H, Brown
PO. 2000. “Functional Characterization of the HIV-1
Genome by Genetic Footprinting.” Journal of Virology,
74(6):2760-2769. |
 |
Lodi PJ;
Chang LC; Knowles JR; Komives EA. 1994. "Triosephosphate
isomerase requires a positively charged active site: the
role of lysine-12." Biochemistry. 33(10):2809-14. |
 |
Perry KM,
Carreras CW, Chang LC, Santi DV, Stroud
RM. 1993. "Structures of thymidylate synthase with a
C-terminal deletion: role of the C-terminus in
alignment of 2'-deoxyuridine 5'- monophosphate and
5,10-methylenetetrahydrofolate." Biochemistry.
32(28):7116-25. |
|
Patwardhan S,
Gashler A, Siegel MG, Chang LC, Joseph
LJ, Shows TB, Le Beau MM, Sukhatme VP. 1991. "EGR3, a
novel member of the Egr family of genes encoding
immediate early transcription factors." Oncogene.
6(6):917-28. |
|
Komives EA,
Chang LC, Lolis E, Tilton RF, Petsko
GA, Knowles JR. 1991. "Electrophilic catalysis in
triosephosphate isomerase: the role of histidine-95."
Biochemistry. 30(12):3011-9. |
|
Sukhatme VP, Cao
X, Chang LC, Tsai-Morris C-H,
Stamenkovich D, Ferreira PCP, Cohen DR, Edwards SA,
Shows TB, Curran T, Le Beau MM, Adamson ED. 1988. "A
zinc finger-encoding gene coregulated with c-fos during
growth and differentiation, and after cellular
depolarization." Cell. 53:37-43. |
 |
Joseph LJ,
Chang LC, Stamenkovich D, Sukhatme VP.
1988. "Complete nucleotide and deduced amino acid
sequences of human and murine preprocathepsin L, an
abundant transcript induced by transformation of
fibroblasts." Journal of Clinical Investigation.
81:1621-1629. |