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Division of Reproductive Endocrinology and Infertility |
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Department of Reproductive Medicine |
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Coss Lab Home Page |
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Welcome to the Coss Lab. Our laboratory aims to answer how the endocrine cell integrates the panoply of neuroendocrine and peripheral hormonal signals, in addition to metabolic cues and environmental insults, to result in the precise rhythm of synthesis and a delicate balance of hormones that regulate homeostasis. Normal endocrine function, which ultimately controls physiology, requires the precise orchestration and integration of hormonal signals, primarily at the level of gene expression. Dysfunction at the level of gene expression, and, therefore hormone concentration, leads to pathophysiologic disorders. Perturbation of hormone levels in mothers during pregnancy has long-reaching consequences that affect the adult physiology of the progeny. Hence, understanding the molecular mechanisms that affect gene expression in the endocrine system will provide insight into the physiology and pathophysiology of mammalian systems. We focus on pituitary gonadotrope cells as a central point of integration of neuroendocrine signals, gonadal feedback and environmental cues, to identify signaling mechanisms that differentially regulate the synthesis of gonadotropin hormones that control steroidogenesis and gametogenesis and aid in overcoming infertility problems as well as in developing novel contraceptive approaches. More detail on the specific projects can be seen by selecting the “research interest” link. |
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Djurdjica Coss, Ph.D. Assistant Professor Department of Reproductive Medicine 9500 Gilman Drive, #0674 University of California, San Diego La Jolla, CA 92093 Phone: 858-822-7693 Email: dcoss@ucsd.edu
Assistant: Kristal Cerimele Phone: 858-534-1140 Email: kcerimele@ucsd.edu
Office: Leichtag Biomedical Research Building, 3A17
Lab: Leichtag Biomedical Research Building, 332, Bays EE and FF |
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To contact us: |
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Education and Training: · University of California, Riverside, CA. Ph.D. in Biomedical Sciences, 2000 · University of California, San Diego, CA. Postdoctoral Fellow, 2000 - 2005 · University of California, San Diego, CA. Research Scientist, 2005 - 2009 |